So no just because you take medicine like Tramadol does not mean you are going to have a poorly babe it could just be fait. What Precautions Should You Take When Taking Tramadol and Tylenol 3 Together? So please until you get this all figured out don't take the two together. Being a resident of the UK it is very hard to even get opiate based pain medication in the first place as they are strictly controlled. Tramadol and hydrocodone are prescription narcotic pain medications. Turturro and associates conducted a randomized, double-blind, prospective study to evaluate the analgesic effect of oral tramadol hydrochloride versus oral hydrocodone with acetaminophen in patients with acute musculoskeletal pain after minor trauma. The authors conclude that tramadol hydrochloride is less effective in the management of acute pain in patients with musculoskeletal pain following trauma than hydrocodone with acetaminophen. According to the Journal of Pain Research, hydrocodone is responsible for some of the highest rates of emergency room visits by people who have overdosed on opioids.However, it is also possible to overdose on tramadol. The risk of overdosing on tramadol may be higher when people are using tramadol with alcohol or other central nervous system depressants. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. These medications should be taken with great care because they can become habit-forming.If you become dependent on opioids, you may have symptoms of withdrawal when you stop. The medication may make it difficult for them to urinate or have a bowel movement. Another medication, Ultracet, is a combination of tramadol and acetaminophen.Vicodin is a brand-name drug containing hydrocodone and acetaminophen. The drug may work better for nerve pain.Vicodin is a combination of the drugs hydrocodone and acetaminophen. If your kidney or liver function is impaired, your doctor may decide that tramadol is not appropriate for you.